Endocrine Abstracts

Genetic instability, i.e. loss of heterozygosity (LOH) and microsatellite instability (MSI) represent molecular disorders acquired by the cell during neoplastic transformation. Genetic instability is a frequent molecular event in thyroid pathogenesis, found at the early and the late stages of thyroid tumorigenesis. In thyroid neoplasms genetic instability was found in many chromosomal regions and is observed especially in cell-derived thyroid tumours. Alterations in PTEN loci ...

The genetic instability, i.e. loss of heterozygosity (LOH) and microsatellite instability (MSI) are frequent molecular events in thyroid tumour aetiopathogenesis. They were found in several chromosomal critical areas, including 3p12–p21.2, 3p24.2–p25.3, 7q21.1–q31.2, 10q22–24, and 15q11–q13, with loci of oncogenes and tumour suppressor genes.Aim of the study: Evaluation of usefulness of LOH/MSI as diagnostic/prognostic biomarker ...

The search for new differentiating biomarkers in follicular-cell derived thyroid tumors (FCDT), especially for the FNAB with underdetermined cytology, is an important scientific task. Disturbed expression of tumor suppressor genes plays important role in thyroid carcinogenesis. In this study we focused on epigenetic mechanism influencing on trefoil factor 3 (TFF3) and tissue inhibitor of metalloproteinases 3 (TIMP3) expression.Aim of the study: Evaluatio...